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TitleA Conserved Kinase-Based Body-Temperature Sensor Globally Controls Alternative Splicing and Gene Expression.
Journal, issue, pagesMol. Cell, Vol. 78, Page 57-69.e4, Year 2020
Publish dateJan 12, 2020 (structure data deposition date)
AuthorsHaltenhof, T. / Kotte, A. / De Bortoli, F. / Schiefer, S. / Meinke, S. / Emmerichs, A.K. / Petermann, K.K. / Timmermann, B. / Imhof, P. / Franz, A. ...Haltenhof, T. / Kotte, A. / De Bortoli, F. / Schiefer, S. / Meinke, S. / Emmerichs, A.K. / Petermann, K.K. / Timmermann, B. / Imhof, P. / Franz, A. / Loll, B. / Wahl, M.C. / Preussner, M. / Heyd, F.
External linksMol. Cell / PubMed:32059760
MethodsX-ray diffraction
Resolution1.8 Å
Structure data

PDB-6tw2:
Re-refined crystal structure of di-phosphorylated human CLK1 in complex with a novel substituted indole inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

Chemicals

ChemComp-V25:
ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / SERINE/THREONINE-PROTEIN KINASE / TYROSINE-PROTEIN KINASE / NUCLEUS

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