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Structure paper

TitleCasein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch.
Journal, issue, pagesElife, Vol. 9, Year 2020
Publish dateJul 26, 2019 (structure data deposition date)
AuthorsPhilpott, J.M. / Narasimamurthy, R. / Ricci, C.G. / Freeberg, A.M. / Hunt, S.R. / Yee, L.E. / Pelofsky, R.S. / Tripathi, S. / Virshup, D.M. / Partch, C.L.
External linksElife / PubMed:32043967
MethodsX-ray diffraction
Resolution1.551 - 2.35 Å
Structure data

PDB-6pxn:
Human Casein Kinase 1 delta Tau mutant (R178C)
Method: X-RAY DIFFRACTION / Resolution: 1.551 Å

PDB-6pxo:
Human Casein Kinase 1 delta (anion-free crystallization conditions)
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-6pxp:
Human Casein Kinase 1 delta Site 2 mutant (K171E)
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCIRCADIAN CLOCK PROTEIN/TRANSFERASE / Kinase / serine-threonine kinase / CIRCADIAN CLOCK PROTEIN / CIRCADIAN CLOCK PROTEIN-TRANSFERASE complex

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