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Structure paper

TitleStructural insights into the promutagenic bypass of the major cisplatin-induced DNA lesion.
Journal, issue, pagesBiochem. J., Vol. 477, Page 937-951, Year 2020
Publish dateAug 29, 2019 (structure data deposition date)
AuthorsOuzon-Shubeita, H. / Vilas, C.K. / Lee, S.
External linksBiochem. J. / PubMed:32039434
MethodsX-ray diffraction
Resolution3.108 Å
Structure data

PDB-6u6b:
Structure of human DNA polymerase beta misinserting dAMPNPP opposite the 5'G of the cisplatin Pt-GG intrastrand crosslink with Manganese in the active site
Method: X-RAY DIFFRACTION / Resolution: 3.108 Å

Chemicals

ChemComp-MN:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-DZ4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

ChemComp-CPT:
Cisplatin / medication, chemotherapy*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/DNA / polymerase / cisplatin / mismatch / Pt-GG / TRANSFERASE / TRANSFERASE-DNA complex

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