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Structure paper

TitleAn optimized chemical-genetic method for cell-specific metabolic labeling of RNA.
Journal, issue, pagesNat. Methods, Vol. 17, Page 311-318, Year 2020
Publish dateNov 21, 2018 (structure data deposition date)
AuthorsNainar, S. / Cuthbert, B.J. / Lim, N.M. / England, W.E. / Ke, K. / Sophal, K. / Quechol, R. / Mobley, D.L. / Goulding, C.W. / Spitale, R.C.
External linksNat. Methods / PubMed:32015544
MethodsX-ray diffraction
Resolution2.424 - 3.085 Å
Structure data

PDB-6n53:
Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine monophosphate
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6n54:
Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidocytidine monophosphate
Method: X-RAY DIFFRACTION / Resolution: 2.424 Å

PDB-6n55:
Crystal structure of human uridine-cytidine kinase 2 complexed with 2'-azidouridine
Method: X-RAY DIFFRACTION / Resolution: 3.085 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-UZR:
2'-deoxy-2'-triaza-1,2-dien-2-ium-1-yl-uridine-5'-monophosphate

ChemComp-HOH:
WATER

ChemComp-KEA:
2'-azido-2'-deoxycytidine 5'-(dihydrogen phosphate)

ChemComp-UZ0:
2'-azido-2'-deoxyuridine

Source
  • homo sapiens (human)
KeywordsCYTOSOLIC PROTEIN / Uridine-cytidine kinase 2 / UCK2 / Kinase / Complex / Azide

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