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-Structure paper
Title | Biomimetic Macrocyclic Inhibitors of Human Cathepsin D: Structure-Activity Relationship and Binding Mode Analysis. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 1576-1596, Year 2020 |
Publish date | Dec 21, 2018 (structure data deposition date) |
![]() | Houstecka, R. / Hadzima, M. / Fanfrlik, J. / Brynda, J. / Pallova, L. / Hanova, I. / Mertlikova-Kaiserova, H. / Lepsik, M. / Horn, M. / Smrcina, M. ...Houstecka, R. / Hadzima, M. / Fanfrlik, J. / Brynda, J. / Pallova, L. / Hanova, I. / Mertlikova-Kaiserova, H. / Lepsik, M. / Horn, M. / Smrcina, M. / Majer, P. / Mares, M. |
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Methods | X-ray diffraction |
Resolution | 1.55 - 1.85 Å |
Structure data | ![]() PDB-6qbg: ![]() PDB-6qbh: ![]() PDB-6qcb: |
Chemicals | ![]() ChemComp-HVT: ![]() ChemComp-DMS: ![]() ChemComp-NAG: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-S43: ![]() ChemComp-PO3: ![]() ChemComp-HWE: |
Source |
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![]() | HYDROLASE / aspartic protease / peptidomimetic inhibitor |