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TitleStructure-guided discovery of a single-domain antibody agonist against human apelin receptor.
Journal, issue, pagesSci Adv, Vol. 6, Page eaax7379-eaax7379, Year 2020
Publish dateAug 6, 2019 (structure data deposition date)
AuthorsMa, Y. / Ding, Y. / Song, X. / Ma, X. / Li, X. / Zhang, N. / Song, Y. / Sun, Y. / Shen, Y. / Zhong, W. ...Ma, Y. / Ding, Y. / Song, X. / Ma, X. / Li, X. / Zhang, N. / Song, Y. / Sun, Y. / Shen, Y. / Zhong, W. / Hu, L.A. / Zhang, M.Y.
External linksSci Adv / PubMed:31998837
MethodsX-ray diffraction
Resolution3.2 Å
Structure data

PDB-6knm:
Apelin receptor in complex with single domain antibody
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • clostridium pasteurianum (bacteria)
  • camelus bactrianus (Bactrian camel)
KeywordsMEMBRANE PROTEIN / GPCR / Single-domain antibody / Antagonist / Agonist

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