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-Structure paper
Title | Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. |
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Journal, issue, pages | Nature, Vol. 578, Page 306-310, Year 2020 |
Publish date | Jul 25, 2018 (structure data deposition date) |
Authors | Faivre, E.J. / McDaniel, K.F. / Albert, D.H. / Mantena, S.R. / Plotnik, J.P. / Wilcox, D. / Zhang, L. / Bui, M.H. / Sheppard, G.S. / Wang, L. ...Faivre, E.J. / McDaniel, K.F. / Albert, D.H. / Mantena, S.R. / Plotnik, J.P. / Wilcox, D. / Zhang, L. / Bui, M.H. / Sheppard, G.S. / Wang, L. / Sehgal, V. / Lin, X. / Huang, X. / Lu, X. / Uziel, T. / Hessler, P. / Lam, L.T. / Bellin, R.J. / Mehta, G. / Fidanze, S. / Pratt, J.K. / Liu, D. / Hasvold, L.A. / Sun, C. / Panchal, S.C. / Nicolette, J.J. / Fossey, S.L. / Park, C.H. / Longenecker, K. / Bigelow, L. / Torrent, M. / Rosenberg, S.H. / Kati, W.M. / Shen, Y. |
External links | Nature / PubMed:31969702 |
Methods | X-ray diffraction |
Resolution | 1.98 - 2.44 Å |
Structure data | PDB-6e6j: PDB-6ony: |
Chemicals | ChemComp-HWV: ChemComp-HOH: ChemComp-EDO: |
Source |
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Keywords | SIGNALING PROTEIN / BET / BRD2 / inhibitor |