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Structure paper

TitleDesign of Organo-Peptides As Bipartite PCSK9 Antagonists.
Journal, issue, pagesAcs Chem. Biol., Vol. 15, Page 425-436, Year 2020
Publish dateAug 19, 2019 (structure data deposition date)
AuthorsBurdick, D.J. / Skelton, N.J. / Ultsch, M. / Beresini, M.H. / Eigenbrot, C. / Li, W. / Zhang, Y. / Nguyen, H. / Kong-Beltran, M. / Quinn, J.G. / Kirchhofer, D.
External linksAcs Chem. Biol. / PubMed:31962046
MethodsX-ray diffraction
Resolution2.9 - 2.94 Å
Structure data

PDB-6u2f:
PCSK9-Fab 7G7 complex bound to cis-1-amino-4-phenylcyclohexaneacyl-WNLK(hR)IGLLR - NH2
Method: X-RAY DIFFRACTION / Resolution: 2.94 Å

PDB-6u3i:
Design of organo-peptides as bipartite PCSK9 antagonists
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsHYDROLASE/HYDROLASE INHIBITOR/IMMUNE SYSTEM / Inhibitor / complex / HYDROLASE-HYDROLASE INHIBITOR-IMMUNE SYSTEM complex

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