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Structure paper

TitleThe inactive C-terminal cassette of the dual-cassette RNA helicase BRR2 both stimulates and inhibits the activity of the N-terminal helicase unit.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 2097-2112, Year 2020
Publish dateJul 10, 2019 (structure data deposition date)
AuthorsVester, K. / Santos, K.F. / Kuropka, B. / Weise, C. / Wahl, M.C.
External linksJ. Biol. Chem. / PubMed:31914407
MethodsX-ray diffraction
Resolution2.391 - 3.172 Å
Structure data

PDB-6s8o:
Human Brr2 Helicase Region M641C/A1582C
Method: X-RAY DIFFRACTION / Resolution: 3.172 Å

PDB-6s8q:
Human Brr2 Helicase Region in complex with C-tail deleted Jab1
Method: X-RAY DIFFRACTION / Resolution: 2.391 Å

PDB-6s9i:
Human Brr2 Helicase Region D534C/N1866C in complex with C-tail deleted Jab1
Method: X-RAY DIFFRACTION / Resolution: 2.598 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsHYDROLASE / RNP REMODELING / PRE-MRNA SPLICING / SPLICEOSOME CATALYTIC ACTIVATION / DEXD/H-BOX RNA HELICASE / RNA AND ATP BINDING / NUCLEUS

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