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Structure paper

TitleN-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists.
Journal, issue, pagesChem. Biol. Drug Des., Vol. 95, Page 412-426, Year 2020
Publish dateApr 29, 2019 (structure data deposition date)
AuthorsBaggio, C. / Udompholkul, P. / Gambini, L. / Jossart, J. / Salem, A.F. / Hakansson, M. / Perry, J.J.P. / Pellecchia, M.
External linksChem. Biol. Drug Des. / PubMed:31898401
MethodsX-ray diffraction
Resolution2.57 Å
Structure data

PDB-6rjp:
Bfl-1 in complex with alpha helical peptide
Method: X-RAY DIFFRACTION / Resolution: 2.57 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsPEPTIDE BINDING PROTEIN / protein-protein interactions / stapled alpha helix / covalent inhibitor / Bcl2-2 family proteins

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