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TitleBlocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
Journal, issue, pagesSci Adv, Vol. 5, Page eaax9586-eaax9586, Year 2019
Publish dateDec 21, 2018 (structure data deposition date)
AuthorsBlumberg, L.J. / Humphries, J.E. / Jones, S.D. / Pearce, L.B. / Holgate, R. / Hearn, A. / Cheung, J. / Mahmood, A. / Del Tito, B. / Graydon, J.S. ...Blumberg, L.J. / Humphries, J.E. / Jones, S.D. / Pearce, L.B. / Holgate, R. / Hearn, A. / Cheung, J. / Mahmood, A. / Del Tito, B. / Graydon, J.S. / Stolz, L.E. / Bitonti, A. / Purohit, S. / de Graaf, D. / Kacena, K. / Andersen, J.T. / Christianson, G.J. / Roopenian, D.C. / Hubbard, J.J. / Gandhi, A.K. / Lasseter, K. / Pyzik, M. / Blumberg, R.S.
External linksSci Adv / PubMed:31897428
MethodsX-ray diffraction
Resolution2.381 Å
Structure data

PDB-6nha:
Crystal structure of SYNT001, a human FcRn blocking monoclonal antibody
Method: X-RAY DIFFRACTION / Resolution: 2.381 Å

Chemicals

ChemComp-NHE:
2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / FcRn / B2M / Circulating IgG and IgG immune complex / SYNT001

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