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TitleKappa-on-Heavy (KoH) bodies are a distinct class of fully-human antibody-like therapeutic agents with antigen-binding properties.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 117, Page 292-299, Year 2020
Publish dateJul 29, 2019 (structure data deposition date)
AuthorsMacdonald, L.E. / Meagher, K.A. / Franklin, M.C. / Levenkova, N. / Hansen, J. / Badithe, A.T. / Zhong, M. / Krueger, P. / Rafique, A. / Tu, N. ...Macdonald, L.E. / Meagher, K.A. / Franklin, M.C. / Levenkova, N. / Hansen, J. / Badithe, A.T. / Zhong, M. / Krueger, P. / Rafique, A. / Tu, N. / Shevchuk, J. / Wadhwa, S. / Ehrlich, G. / Bautista, J. / Grant, C. / Esau, L. / Poueymirou, W.T. / Auerbach, W. / Morton, L. / Babb, R. / Chen, G. / Huang, T. / MacDonald, D. / Graham, K. / Gurer, C. / Voronina, V.A. / McWhirter, J.R. / Guo, C. / Yancopoulos, G.D. / Murphy, A.J.
External linksProc. Natl. Acad. Sci. USA / PubMed:31879340
MethodsX-ray diffraction
Resolution2 - 3.6 Å
Structure data

PDB-6pyc:
Structure of kappa-on-heavy (KoH) antibody Fab bound to the cardiac hormone marinobufagenin
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

PDB-6pyd:
Structure of 3E9 antibody Fab bound to marinobufagenin
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-P4S:
(3beta,5beta,14alpha,15beta)-3,5-dihydroxy-14,15-epoxybufa-20,22-dienolide

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Marinobufagenin / antibody engineering / Bence-Jones dimer

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