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Structure paper

TitleT cell receptor cross-reactivity between gliadin and bacterial peptides in celiac disease.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 27, Page 49-61, Year 2020
Publish dateAug 22, 2019 (structure data deposition date)
AuthorsPetersen, J. / Ciacchi, L. / Tran, M.T. / Loh, K.L. / Kooy-Winkelaar, Y. / Croft, N.P. / Hardy, M.Y. / Chen, Z. / McCluskey, J. / Anderson, R.P. ...Petersen, J. / Ciacchi, L. / Tran, M.T. / Loh, K.L. / Kooy-Winkelaar, Y. / Croft, N.P. / Hardy, M.Y. / Chen, Z. / McCluskey, J. / Anderson, R.P. / Purcell, A.W. / Tye-Din, J.A. / Koning, F. / Reid, H.H. / Rossjohn, J.
External linksNat. Struct. Mol. Biol. / PubMed:31873306
MethodsX-ray diffraction
Resolution1.9 - 2.8 Å
Structure data

PDB-6u3m:
DQ2-P.fluor-alpha1a
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-6u3n:
LS2.8/3.15 - DQ2-P.fluor-alpha1a complex
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6u3o:
JR51 DQ2-p.aeru-alpha2a complex
Method: X-RAY DIFFRACTION / Resolution: 2.743 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-PO4:
PHOSPHATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • pseudomonas fluorescens (bacteria)
  • pseudomonas aeruginosa (bacteria)
KeywordsIMMUNE SYSTEM / Immune Complex / Celiac disease / Gliadin epitope / TCR cross-reactivity

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