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TitleHigh-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 142, Page 33-37, Year 2020
Publish dateAug 28, 2019 (structure data deposition date)
AuthorsKhamrui, S. / Ung, P.M.U. / Secor, C. / Schlessinger, A. / Lazarus, M.B.
External linksJ. Am. Chem. Soc. / PubMed:31841327
MethodsX-ray diffraction
Resolution1.75 Å
Structure data

PDB-6u5l:
Structure of human ULK4 in complex with an inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-3RJ:
N~2~-(1H-benzimidazol-6-yl)-N~4~-(5-cyclobutyl-1H-pyrazol-3-yl)quinazoline-2,4-diamine

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/TRANSFERASE Inhibitor / kinase / pseudokinase / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex

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