Movie
Controller
Structure viewers
About Yorodumi Papers
+Search query
-Structure paper
| Title | Discovery of a Covalent Inhibitor of KRASG12C(AMG 510) for the Treatment of Solid Tumors. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 63, Page 52-65, Year 2020 |
| Publish date | Jun 24, 2019 (structure data deposition date) |
 Authors | Lanman, B.A. / Allen, J.R. / Allen, J.G. / Amegadzie, A.K. / Ashton, K.S. / Booker, S.K. / Chen, J.J. / Chen, N. / Frohn, M.J. / Goodman, G. ...Lanman, B.A. / Allen, J.R. / Allen, J.G. / Amegadzie, A.K. / Ashton, K.S. / Booker, S.K. / Chen, J.J. / Chen, N. / Frohn, M.J. / Goodman, G. / Kopecky, D.J. / Liu, L. / Lopez, P. / Low, J.D. / Ma, V. / Minatti, A.E. / Nguyen, T.T. / Nishimura, N. / Pickrell, A.J. / Reed, A.B. / Shin, Y. / Siegmund, A.C. / Tamayo, N.A. / Tegley, C.M. / Walton, M.C. / Wang, H.L. / Wurz, R.P. / Xue, M. / Yang, K.C. / Achanta, P. / Bartberger, M.D. / Canon, J. / Hollis, L.S. / McCarter, J.D. / Mohr, C. / Rex, K. / Saiki, A.Y. / San Miguel, T. / Volak, L.P. / Wang, K.H. / Whittington, D.A. / Zech, S.G. / Lipford, J.R. / Cee, V.J. |
 External links | J. Med. Chem. / PubMed:31820981 |
| Methods | X-ray diffraction |
| Resolution | 1.5 - 1.6 Å |
| Structure data |  PDB-6pgo:  PDB-6pgp: |
| Chemicals |  ChemComp-MG:  ChemComp-GDP:  ChemComp-OJ1:  ChemComp-HOH:  ChemComp-CA:  ChemComp-OHY: |
| Source |
|
 Keywords | SIGNALING PROTEIN/Inhibitor / Inhibitor / GTPase / SIGNALING PROTEIN / SIGNALING PROTEIN-Inhibitor complex |
homo sapiens (human)