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Structure paper

TitleStructural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion.
Journal, issue, pagesPlos Pathog., Vol. 15, Page e1008139-e1008139, Year 2019
Publish dateAug 20, 2018 (structure data deposition date)
AuthorsAbskharon, R. / Wang, F. / Wohlkonig, A. / Ruan, J. / Soror, S. / Giachin, G. / Pardon, E. / Zou, W. / Legname, G. / Ma, J. / Steyaert, J.
External linksPlos Pathog. / PubMed:31815959
MethodsX-ray diffraction
Resolution1.199 - 2.102 Å
Structure data

PDB-6heq:
Prion nanobody 484
Method: X-RAY DIFFRACTION / Resolution: 1.23 Å

PDB-6her:
Mouse prion protein in complex with Nanobody 484
Method: X-RAY DIFFRACTION / Resolution: 1.199 Å

PDB-6hhd:
Mouse Prion Protein in complex with Nanobody 484
Method: X-RAY DIFFRACTION / Resolution: 2.102 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CL:
Unknown entry

ChemComp-NA:
Unknown entry

Source
  • camelus dromedarius (Arabian camel)
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING / Nanobody / aggregation / beta fold / Prion / B-sheet

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