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TitleCycloserine enantiomers are reversible inhibitors of human alanine:glyoxylate aminotransferase: implications for Primary Hyperoxaluria type 1.
Journal, issue, pagesBiochem. J., Vol. 476, Page 3751-3768, Year 2019
Publish dateMay 30, 2019 (structure data deposition date)
AuthorsDindo, M. / Grottelli, S. / Annunziato, G. / Giardina, G. / Pieroni, M. / Pampalone, G. / Faccini, A. / Cutruzzola, F. / Laurino, P. / Costantino, G. / Cellini, B.
External linksBiochem. J. / PubMed:31794008
MethodsX-ray diffraction
Resolution2.7 - 3 Å
Structure data

PDB-6rv0:
human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma); with PMP in the active site
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6rv1:
human Alanine:Glyoxylate Aminotransferase major allele (AGT-Ma)
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-PMP:
4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE

ChemComp-HOH:
WATER

ChemComp-PLP:
PYRIDOXAL-5'-PHOSPHATE

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / AMINOTRANSFERASE / DETOXIFICATION / LIVER

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