タイトル | Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. |
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ジャーナル・号・ページ | J. Med. Chem., Vol. 63, Page 295-308, Year 2020 |
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掲載日 | 2019年8月1日 (構造データの登録日) |
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著者 | Osko, J.D. / Porter, N.J. / Narayana Reddy, P.A. / Xiao, Y.C. / Rokka, J. / Jung, M. / Hooker, J.M. / Salvino, J.M. / Christianson, D.W. |
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リンク | J. Med. Chem. / PubMed:31793776 |
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手法 | X線回折 |
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解像度 | 1.5 - 2.3 Å |
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構造データ | PDB-6pzo: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with YX-153 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-6pzr: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with Resminostat 手法: X-RAY DIFFRACTION / 解像度: 2.3 Å PDB-6pzs: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with JR005 手法: X-RAY DIFFRACTION / 解像度: 1.79 Å PDB-6pzu: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with AP-1-62-A 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-6q0z: Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with JS28 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å |
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化合物 | ChemComp-P6Y: N-{[4-(hydroxycarbamoyl)phenyl]methyl}-2-(trifluoromethyl)pyridine-3-carboxamide
ChemComp-P7J: 4-[({[(1R,2R,5R)-6,6-dimethylbicyclo[3.1.1]heptan-2-yl]methyl}amino)methyl]-N-hydroxybenzamide
ChemComp-A6I: N-[(benzyloxy)carbonyl]-L-leucyl-N-{[4-(hydroxycarbamoyl)phenyl]methyl}-L-alaninamide
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由来 | ![](img/tx_fish.gif) danio rerio (ゼブラフィッシュ)
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キーワード | HYDROLASE/HYDROLASE INHIBITOR / Histone deacetylase / metallohydrolase / HYDROLASE-HYDROLASE INHIBITOR complex |
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