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TitleSynthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.
Journal, issue, pagesAcs Chem. Biol., Vol. 15, Page 205-216, Year 2020
Publish dateSep 4, 2019 (structure data deposition date)
AuthorsKoirala, D. / Lewicka, A. / Koldobskaya, Y. / Huang, H. / Piccirilli, J.A.
External linksAcs Chem. Biol. / PubMed:31765566
MethodsX-ray diffraction
Resolution1.807 - 2.75 Å
Structure data

PDB-6u8d:
Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV2
Method: X-RAY DIFFRACTION / Resolution: 1.807 Å

PDB-6u8k:
Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV3
Method: X-RAY DIFFRACTION / Resolution: 2.75 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • hepacivirus c
KeywordsRNA/Immune System / Internal ribosome entry site (IRES) / hepatitis C virus / Junction IIIabc / Antibody-assisted RNA crystallography / Viral translation / Viral RNA domains / RNA / RNA-Immune System complex

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