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TitleInhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 24881-24891, Year 2019
Publish dateMay 6, 2019 (structure data deposition date)
AuthorsBanerjee, S. / Wei, T. / Wang, J. / Lee, J.J. / Gutierrez, H.L. / Chapman, O. / Wiley, S.E. / Mayfield, J.E. / Tandon, V. / Juarez, E.F. ...Banerjee, S. / Wei, T. / Wang, J. / Lee, J.J. / Gutierrez, H.L. / Chapman, O. / Wiley, S.E. / Mayfield, J.E. / Tandon, V. / Juarez, E.F. / Chavez, L. / Liang, R. / Sah, R.L. / Costello, C. / Mesirov, J.P. / de la Vega, L. / Cooper, K.L. / Dixon, J.E. / Xiao, J. / Lei, X.
External linksProc. Natl. Acad. Sci. USA / PubMed:31754034
MethodsX-ray diffraction
Resolution2.352 Å
Structure data

PDB-6k0j:
The co-crystal structure of DYRK2 with a small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.352 Å

Chemicals

ChemComp-CQO:
3-(2,7-dimethoxyacridin-9-yl)sulfanylpropan-1-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE/INHIBITOR / kinase / TRANSFERASE-INHIBITOR complex

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