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-Structure paper
| Title | Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia. |
|---|---|
| Journal, issue, pages | J. Med. Chem., Vol. 62, Page 11135-11150, Year 2019 |
| Publish date | Jul 30, 2019 (structure data deposition date) |
 Authors | Lin, W.H. / Wu, S.Y. / Yeh, T.K. / Chen, C.T. / Song, J.S. / Shiao, H.Y. / Kuo, C.C. / Hsu, T. / Lu, C.T. / Wang, P.C. ...Lin, W.H. / Wu, S.Y. / Yeh, T.K. / Chen, C.T. / Song, J.S. / Shiao, H.Y. / Kuo, C.C. / Hsu, T. / Lu, C.T. / Wang, P.C. / Wu, T.S. / Peng, Y.H. / Lin, H.Y. / Chen, C.P. / Weng, Y.L. / Kung, F.C. / Wu, M.H. / Su, Y.C. / Huang, K.W. / Chou, L.H. / Hsueh, C.C. / Yen, K.J. / Kuo, P.C. / Huang, C.L. / Chen, L.T. / Shih, C. / Tsai, H.J. / Jiaang, W.T. |
 External links | J. Med. Chem. / PubMed:31721578 |
| Methods | X-ray diffraction |
| Resolution | 2.109 Å |
| Structure data |  PDB-6kla: |
| Chemicals |  ChemComp-DJX:  ChemComp-HOH: |
| Source |
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 Keywords | TRANSFERASE / tyrosine kinase inhibitor / kinase phosphorylation / ATP competitor / transmembrane receptor protein |
homo sapiens (human)