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Title | Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC). |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 11004-11018, Year 2019 |
Publish date | Aug 19, 2019 (structure data deposition date) |
Authors | Ward, R.A. / Anderton, M.J. / Bethel, P. / Breed, J. / Cook, C. / Davies, E.J. / Dobson, A. / Dong, Z. / Fairley, G. / Farrington, P. ...Ward, R.A. / Anderton, M.J. / Bethel, P. / Breed, J. / Cook, C. / Davies, E.J. / Dobson, A. / Dong, Z. / Fairley, G. / Farrington, P. / Feron, L. / Flemington, V. / Gibbons, F.D. / Graham, M.A. / Greenwood, R. / Hanson, L. / Hopcroft, P. / Howells, R. / Hudson, J. / James, M. / Jones, C.D. / Jones, C.R. / Li, Y. / Lamont, S. / Lewis, R. / Lindsay, N. / McCabe, J. / McGuire, T. / Rawlins, P. / Roberts, K. / Sandin, L. / Simpson, I. / Swallow, S. / Tang, J. / Tomkinson, G. / Tonge, M. / Wang, Z. / Zhai, B. |
External links | J. Med. Chem. / PubMed:31710489 |
Methods | X-ray diffraction |
Resolution | 1.33 Å |
Structure data | PDB-6slg: |
Chemicals | ChemComp-LHZ: ChemComp-SO4: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE / ERK2 / KINASE / INHIBITOR / ONCOLOGY |