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Structure paper

TitleStructural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Journal, issue, pagesSci Rep, Vol. 9, Page 16400-16400, Year 2019
Publish dateJul 31, 2019 (structure data deposition date)
AuthorsRechkoblit, O. / Johnson, R.E. / Buku, A. / Prakash, L. / Prakash, S. / Aggarwal, A.K.
External linksSci Rep / PubMed:31704958
MethodsX-ray diffraction
Resolution2.09 - 2.395 Å
Structure data

PDB-6pz3:
Polymerase Eta-catalyzed insertion of correct G opposite template cytarabine (AraC) residue
Method: X-RAY DIFFRACTION / Resolution: 2.395 Å

PDB-6q02:
Polymerase Eta-catalyzed insertion of the mismatched A opposite template cytarabine (AraC) residue
Method: X-RAY DIFFRACTION / Resolution: 2.09 Å

Chemicals

ChemComp-XG4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-DZ4:
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSFERASE / cytarabin / lesion bypass / DNA damage / replication / chemotherapy / TRANSFERASE/DNA / DNA replication / TRANSFERASE-DNA complex

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