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Structure paper

TitleExcision of 5-Carboxylcytosine by Thymine DNA Glycosylase.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 18851-18861, Year 2019
Publish dateAug 15, 2019 (structure data deposition date)
AuthorsPidugu, L.S. / Dai, Q. / Malik, S.S. / Pozharski, E. / Drohat, A.C.
External linksJ. Am. Chem. Soc. / PubMed:31693361
MethodsX-ray diffraction
Resolution1.55 - 2.4 Å
Structure data

PDB-6u15:
Human thymine DNA glycosylase N140A mutant bound to DNA with 2'-F-5-carboxyl-dC substrate analog
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-6u16:
Human thymine DNA glycosylase N140A mutant bound to DNA with 5-carboxyl-dC substrate
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6u17:
Human thymine DNA glycosylase bound to DNA with 2'-F-5-carboxyl-dC substrate analog
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ACT:
ACETATE ION

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / protein-DNA complex / HYDROLASE-DNA complex / DNA BINDING PROTEIN

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