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TitleEffect of Fms-like tyrosine kinase 3 (FLT3) ligand (FL) on antitumor activity of gilteritinib, a FLT3 inhibitor, in mice xenografted with FL-overexpressing cells.
Journal, issue, pagesOncotarget, Vol. 10, Page 6111-6123, Year 2019
Publish dateApr 1, 2019 (structure data deposition date)
AuthorsKawase, T. / Nakazawa, T. / Eguchi, T. / Tsuzuki, H. / Ueno, Y. / Amano, Y. / Suzuki, T. / Mori, M. / Yoshida, T.
External linksOncotarget / PubMed:31692922
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-6jqr:
Crystal structure of FLT3 in complex with gilteritinib
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-C6F:
6-ethyl-3-[[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]amino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide / anticancer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-CXS:
3-CYCLOHEXYL-1-PROPYLSULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / protein kinase / ONCOPROTEIN

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