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TitleStructure of Sonic Hedgehog protein in complex with zinc(II) and magnesium(II) reveals ion-coordination plasticity relevant to peptide drug design.
Journal, issue, pagesActa Crystallogr D Struct Biol, Vol. 75, Page 969-979, Year 2019
Publish dateJun 28, 2019 (structure data deposition date)
AuthorsBonn-Breach, R. / Gu, Y. / Jenkins, J. / Fasan, R. / Wedekind, J.
External linksActa Crystallogr D Struct Biol / PubMed:31692471
MethodsX-ray diffraction
Resolution1.43 Å
Structure data

PDB-6pjv:
Structure of Human Sonic Hedgehog in complex with Zinc and Magnesium
Method: X-RAY DIFFRACTION / Resolution: 1.43 Å

Chemicals

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-GOL:
GLYCEROL

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / HEDGEHOG PROTEINS / SIGNALING / ZINC IONS / Magnesium ions / AUTOCATALYTIC CLEAVAGE DEVELOPMENTAL / PROTEIN / HOLOPROSENCEPHALY / SECRETED / sonic hedgehog / SHH / SHH-N

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