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Structure paper

TitleAn engineered antibody fragment targeting mutant beta-catenin via major histocompatibility complex I neoantigen presentation.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 19322-19334, Year 2019
Publish dateMar 13, 2019 (structure data deposition date)
AuthorsMiller, M.S. / Douglass, J. / Hwang, M.S. / Skora, A.D. / Murphy, M. / Papadopoulos, N. / Kinzler, K.W. / Vogelstein, B. / Zhou, S. / Gabelli, S.B.
External linksJ. Biol. Chem. / PubMed:31690625
MethodsX-ray diffraction
Resolution2.2 - 2.45 Å
Structure data

PDB-6o9b:
Crystal structure of HLA-A3*01 in complex with a wild-type beta-catenin peptide
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-6o9c:
Crystal structure of HLA-A3*01 in complex with a mutant beta-catenin peptide
Method: X-RAY DIFFRACTION / Resolution: 2.45 Å

Chemicals

ChemComp-PG4:
TETRAETHYLENE GLYCOL / precipitant*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-IMD:
IMIDAZOLE

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / HLA-A3 / MHC Class I / beta catenin

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