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-Structure paper
Title | Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors. |
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Journal, issue, pages | Sci Rep, Vol. 9, Page 15893-15893, Year 2019 |
Publish date | Mar 2, 2018 (structure data deposition date) |
Authors | Kufareva, I. / Bestgen, B. / Brear, P. / Prudent, R. / Laudet, B. / Moucadel, V. / Ettaoussi, M. / Sautel, C.F. / Krimm, I. / Engel, M. ...Kufareva, I. / Bestgen, B. / Brear, P. / Prudent, R. / Laudet, B. / Moucadel, V. / Ettaoussi, M. / Sautel, C.F. / Krimm, I. / Engel, M. / Filhol, O. / Borgne, M.L. / Lomberget, T. / Cochet, C. / Abagyan, R. |
External links | Sci Rep / PubMed:31685885 |
Methods | X-ray diffraction |
Resolution | 1.47 - 1.6 Å |
Structure data | PDB-6fvf: PDB-6fvg: |
Chemicals | ChemComp-503: ChemComp-ATP: ChemComp-HOH: ChemComp-E8K: |
Source |
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Keywords | TRANSFERASE / CK2alpha / CK2a / fragment based drug discovery / high concentration screening / selective ATP competitive inhibitors / surface entrophy reduction |