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TitleGeneral Base Swap Preserves Activity and Expands Substrate Tolerance in Hedgehog Autoprocessing.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 18380-18384, Year 2019
Publish dateAug 9, 2019 (structure data deposition date)
AuthorsZhao, J. / Ciulla, D.A. / Xie, J. / Wagner, A.G. / Castillo, D.A. / Zwarycz, A.S. / Lin, Z. / Beadle, S. / Giner, J.L. / Li, Z. ...Zhao, J. / Ciulla, D.A. / Xie, J. / Wagner, A.G. / Castillo, D.A. / Zwarycz, A.S. / Lin, Z. / Beadle, S. / Giner, J.L. / Li, Z. / Li, H. / Banavali, N. / Callahan, B.P. / Wang, C.
External linksJ. Am. Chem. Soc. / PubMed:31682419
MethodsX-ray diffraction
Resolution1.36 Å
Structure data

PDB-6tyy:
Hedgehog autoprocessing mutant D46H
Method: X-RAY DIFFRACTION / Resolution: 1.36 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
KeywordsSIGNALING PROTEIN / Hedgehog autoprocessing doamin

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