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Structure paper

TitlePseudouridinylation of mRNA coding sequences alters translation.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 23068-23074, Year 2019
Publish dateOct 14, 2019 (structure data deposition date)
AuthorsEyler, D.E. / Franco, M.K. / Batool, Z. / Wu, M.Z. / Dubuke, M.L. / Dobosz-Bartoszek, M. / Jones, J.D. / Polikanov, Y.S. / Roy, B. / Koutmou, K.S.
External linksProc. Natl. Acad. Sci. USA / PubMed:31672910
MethodsX-ray diffraction
Resolution2.95 Å
Structure data

PDB-6uo1:
Crystal structure of the Thermus thermophilus 70S ribosome in complex with mRNA (containing pseudouridine at the first position of the codon) and deacylated A-, P-, and E-site tRNAs at 2.95A resolution
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

ChemComp-SF4:
IRON/SULFUR CLUSTER

ChemComp-HOH:
WATER

Source
  • thermus thermophilus hb8 (bacteria)
  • thermus thermophilus (strain hb8 / atcc 27634 / dsm 579) (bacteria)
  • escherichia virus t4
  • escherichia coli (E. coli)
KeywordsRIBOSOME / Pseudouridine / mRNA / modification / translation / peptidyl transferase center / tRNA accommodation

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