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Title | Trifluoromethyl Dihydrothiazine-Based beta-Secretase (BACE1) Inhibitors with Robust Central beta-Amyloid Reduction and Minimal Covalent Binding Burden. |
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Journal, issue, pages | Chemmedchem, Vol. 14, Page 1894-1910, Year 2019 |
Publish date | Apr 8, 2019 (structure data deposition date) |
![]() | Anan, K. / Iso, Y. / Oguma, T. / Nakahara, K. / Suzuki, S. / Yamamoto, T. / Matsuoka, E. / Ito, H. / Sakaguchi, G. / Ando, S. ...Anan, K. / Iso, Y. / Oguma, T. / Nakahara, K. / Suzuki, S. / Yamamoto, T. / Matsuoka, E. / Ito, H. / Sakaguchi, G. / Ando, S. / Morimoto, K. / Kanegawa, N. / Kido, Y. / Kawachi, T. / Fukushima, T. / Teisman, A. / Urmaliya, V. / Dhuyvetter, D. / Borghys, H. / Austin, N. / Van Den Bergh, A. / Verboven, P. / Bischoff, F. / Gijsen, H.J.M. / Yamano, Y. / Kusakabe, K. |
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Methods | X-ray diffraction |
Resolution | 2.2 Å |
Structure data | ![]() PDB-6jt4: |
Chemicals | ![]() ChemComp-IOD: ![]() ChemComp-GOL: ![]() ChemComp-C86: ![]() ChemComp-HOH: |
Source |
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![]() | HYDROLASE / GS-hBACE1(43-454) |