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Title | From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. |
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Journal, issue, pages | Cell Chem Biol, Vol. 27, Page 32-40.e3, Year 2020 |
Publish date | Aug 19, 2019 (structure data deposition date) |
![]() | Petrilli, W.L. / Adam, G.C. / Erdmann, R.S. / Abeywickrema, P. / Agnani, V. / Ai, X. / Baysarowich, J. / Byrne, N. / Caldwell, J.P. / Chang, W. ...Petrilli, W.L. / Adam, G.C. / Erdmann, R.S. / Abeywickrema, P. / Agnani, V. / Ai, X. / Baysarowich, J. / Byrne, N. / Caldwell, J.P. / Chang, W. / DiNunzio, E. / Feng, Z. / Ford, R. / Ha, S. / Huang, Y. / Hubbard, B. / Johnston, J.M. / Kavana, M. / Lisnock, J.M. / Liang, R. / Lu, J. / Lu, Z. / Meng, J. / Orth, P. / Palyha, O. / Parthasarathy, G. / Salowe, S.P. / Sharma, S. / Shipman, J. / Soisson, S.M. / Strack, A.M. / Youm, H. / Zhao, K. / Zink, D.L. / Zokian, H. / Addona, G.H. / Akinsanya, K. / Tata, J.R. / Xiong, Y. / Imbriglio, J.E. |
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Methods | X-ray diffraction |
Resolution | 1.53 - 2.73 Å |
Structure data | ![]() PDB-6u26: ![]() PDB-6u2n: ![]() PDB-6u2p: ![]() PDB-6u36: ![]() PDB-6u38: ![]() PDB-6u3x: |
Chemicals | ![]() ChemComp-063: ![]() ChemComp-HOH: ![]() ChemComp-PV7: ![]() ChemComp-EDO: ![]() ChemComp-PUV: ![]() ChemComp-PVM: ![]() ChemComp-PVJ: ![]() ChemComp-PVV: |
Source |
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![]() | HYDROLASE/HYDROLASE Inhibitor / CHOLESTEROL CLEARANCE / PCSK9 / LDLR / Autocatalytic cleavage / Cholesterol metabolism / Disulfide bond / Glycoprotein / Hydrolase / Lipid metabolism / Phosphoprotein / Protease / Secreted / Serine protease / inhibitor / HYDROLASE-HYDROLASE Inhibitor complex / Serine Type Endopeptidase Activity Proteolysis / HYDROLASE/Immune System / HYDROLASE-Immune System complex |