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TitlePrebiotically Plausible "Patching" of RNA Backbone Cleavage through a 3'-5' Pyrophosphate Linkage.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 141, Page 18104-18112, Year 2019
Publish dateAug 29, 2019 (structure data deposition date)
AuthorsWright, T.H. / Giurgiu, C. / Zhang, W. / Radakovic, A. / O'Flaherty, D.K. / Zhou, L. / Szostak, J.W.
External linksJ. Am. Chem. Soc. / PubMed:31651170
MethodsX-ray diffraction
Resolution1.6 Å
Structure data

PDB-6u6j:
RNA-monomer complex containing pyrophosphate linkage
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-EQ4:
5'-O-[(R)-(2-amino-1H-imidazol-1-yl)(hydroxy)phosphoryl]guanosine

ChemComp-HOH:
WATER

Source
  • synthetic construct (others)
KeywordsRNA / pyrophosphate

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