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TitleAtypical KRASG12RMutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer.
Journal, issue, pagesCancer Discov, Vol. 10, Page 104-123, Year 2020
Publish dateMar 23, 2018 (structure data deposition date)
AuthorsHobbs, G.A. / Baker, N.M. / Miermont, A.M. / Thurman, R.D. / Pierobon, M. / Tran, T.H. / Anderson, A.O. / Waters, A.M. / Diehl, J.N. / Papke, B. ...Hobbs, G.A. / Baker, N.M. / Miermont, A.M. / Thurman, R.D. / Pierobon, M. / Tran, T.H. / Anderson, A.O. / Waters, A.M. / Diehl, J.N. / Papke, B. / Hodge, R.G. / Klomp, J.E. / Goodwin, C.M. / DeLiberty, J.M. / Wang, J. / Ng, R.W.S. / Gautam, P. / Bryant, K.L. / Esposito, D. / Campbell, S.L. / Petricoin 3rd, E.F. / Simanshu, D.K. / Aguirre, A.J. / Wolpin, B.M. / Wennerberg, K. / Rudloff, U. / Cox, A.D. / Der, C.J.
External linksCancer Discov / PubMed:31649109
MethodsX-ray diffraction
Resolution1.5 Å
Structure data

PDB-6cu6:
Crystal structure of GMPPNP-bound G12R mutant of human KRAS4b
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsONCOPROTEIN / KRAS / RAS / G12R / G12 / KRAS4b / K-RAS

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