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Structure paper

TitleVISTA is an acidic pH-selective ligand for PSGL-1.
Journal, issue, pagesNature, Vol. 574, Page 565-570, Year 2019
Publish dateOct 26, 2018 (structure data deposition date)
AuthorsJohnston, R.J. / Su, L.J. / Pinckney, J. / Critton, D. / Boyer, E. / Krishnakumar, A. / Corbett, M. / Rankin, A.L. / Dibella, R. / Campbell, L. ...Johnston, R.J. / Su, L.J. / Pinckney, J. / Critton, D. / Boyer, E. / Krishnakumar, A. / Corbett, M. / Rankin, A.L. / Dibella, R. / Campbell, L. / Martin, G.H. / Lemar, H. / Cayton, T. / Huang, R.Y. / Deng, X. / Nayeem, A. / Chen, H. / Ergel, B. / Rizzo, J.M. / Yamniuk, A.P. / Dutta, S. / Ngo, J. / Shorts, A.O. / Ramakrishnan, R. / Kozhich, A. / Holloway, J. / Fang, H. / Wang, Y.K. / Yang, Z. / Thiam, K. / Rakestraw, G. / Rajpal, A. / Sheppard, P. / Quigley, M. / Bahjat, K.S. / Korman, A.J.
External linksNature / PubMed:31645726
MethodsX-ray diffraction
Resolution1.61 Å
Structure data

PDB-6mvl:
Crystal structure of VISTA bound to a pH-selective antibody Fab fragment
Method: X-RAY DIFFRACTION / Resolution: 1.61 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / immunoglobulin / checkpoint / antibody / complex

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