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-Structure paper
Title | Discovery of a Potent, Selective, and Orally Available MTHFD2 Inhibitor (DS18561882) with in Vivo Antitumor Activity. |
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Journal, issue, pages | J. Med. Chem., Vol. 62, Page 10204-10220, Year 2019 |
Publish date | Jul 10, 2019 (structure data deposition date) |
Authors | Kawai, J. / Toki, T. / Ota, M. / Inoue, H. / Takata, Y. / Asahi, T. / Suzuki, M. / Shimada, T. / Ono, K. / Suzuki, K. ...Kawai, J. / Toki, T. / Ota, M. / Inoue, H. / Takata, Y. / Asahi, T. / Suzuki, M. / Shimada, T. / Ono, K. / Suzuki, K. / Takaishi, S. / Ohki, H. / Matsui, S. / Tsutsumi, S. / Hirota, Y. / Nakayama, K. |
External links | J. Med. Chem. / PubMed:31638799 |
Methods | X-ray diffraction |
Resolution | 2.25 Å |
Structure data | PDB-6kg2: |
Chemicals | ChemComp-D8C: ChemComp-NAD: ChemComp-PO4: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / INHIBITOR / FOLATE / COFACTOR / DEHYDROGENASE |