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Structure paper

TitleElucidation of a sialic acid metabolism pathway in mucus-foraging Ruminococcus gnavus unravels mechanisms of bacterial adaptation to the gut.
Journal, issue, pagesNat Microbiol, Vol. 4, Page 2393-2404, Year 2019
Publish dateApr 5, 2019 (structure data deposition date)
AuthorsBell, A. / Brunt, J. / Crost, E. / Vaux, L. / Nepravishta, R. / Owen, C.D. / Latousakis, D. / Xiao, A. / Li, W. / Chen, X. ...Bell, A. / Brunt, J. / Crost, E. / Vaux, L. / Nepravishta, R. / Owen, C.D. / Latousakis, D. / Xiao, A. / Li, W. / Chen, X. / Walsh, M.A. / Claesen, J. / Angulo, J. / Thomas, G.H. / Juge, N.
External linksNat Microbiol / PubMed:31636419
MethodsX-ray diffraction
Resolution1.6 - 1.96 Å
Structure data

PDB-6rab:
Ruminococcus gnavus sialic acid aldolase Wild Type
Method: X-RAY DIFFRACTION / Resolution: 1.96 Å

PDB-6rb7:
Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-6rd1:
Ruminococcus gnavus sialic acid aldolase catalytic lysine mutant in complex with sialic acid
Method: X-RAY DIFFRACTION / Resolution: 1.892 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-GOL:
GLYCEROL

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-BCN:
BICINE / pH buffer*YM

ChemComp-MG:
Unknown entry

ChemComp-SI3:
5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid

Source
  • ruminococcus gnavus atcc 29149 (bacteria)
  • [ruminococcus] gnavus atcc 29149 (bacteria)
KeywordsLYASE / Neu5Ac / sialic acid / aldolase / ruminococcus gnavus

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