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Structure paper

TitleStructural basis of temperature sensation by the TRP channel TRPV3.
Journal, issue, pagesNat Struct Mol Biol, Vol. 26, Issue 11, Page 994-998, Year 2019
Publish dateOct 21, 2019
AuthorsAppu K Singh / Luke L McGoldrick / Lusine Demirkhanyan / Merfilius Leslie / Eleonora Zakharian / Alexander I Sobolevsky /
PubMed AbstractWe present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first ...We present structures of mouse TRPV3 in temperature-dependent open, closed and intermediate states that suggest two-step activation of TRPV3 by heat. During the strongly temperature-dependent first step, sensitization, the channel pore remains closed while S6 helices undergo α-to-π transitions. During the weakly temperature-dependent second step, channel opening, tight association of the S1-S4 and pore domains is stabilized by changes in the carboxy-terminal and linker domains.
External linksNat Struct Mol Biol / PubMed:31636415 / PubMed Central
MethodsEM (single particle)
Resolution4.07 - 5.18 Å
Structure data

20492

6pvl

EMDB-20492, PDB-6pvl:
Cryo-EM structure of mouse TRPV3 in closed state at 42 degrees Celsius
Method: EM (single particle) / Resolution: 4.4 Å

20493

6pvm

EMDB-20493, PDB-6pvm:
Cryo-EM structure of mouse TRPV3 in putative sensitized state at 42 degrees Celsius
Method: EM (single particle) / Resolution: 4.5 Å

20494

6pvn

EMDB-20494, PDB-6pvn:
Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 4 degrees Celsius
Method: EM (single particle) / Resolution: 4.07 Å

20495

6pvo

EMDB-20495, PDB-6pvo:
Cryo-EM structure of mouse TRPV3-Y564A in putative sensitized state at 37 degrees Celsius
Method: EM (single particle) / Resolution: 5.18 Å

20496

6pvp

EMDB-20496, PDB-6pvp:
Cryo-EM structure of mouse TRPV3-Y564A in open state at 37 degrees Celsius
Method: EM (single particle) / Resolution: 4.48 Å

20497

6pvq

EMDB-20497, PDB-6pvq:
Cryo-EM structure of mouse TRPV3-Y564A in intermediate state at 37 degrees Celsius
Method: EM (single particle) / Resolution: 4.75 Å

Chemicals

ChemComp-NA:
Unknown entry

Source
  • mus musculus (house mouse)
KeywordsTRANSPORT PROTEIN / Ion Channels / Membrane Protein / TRP Channels

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