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TitleEnhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis.
Journal, issue, pagesLife Sci Alliance, Vol. 2, Year 2019
Publish dateApr 16, 2019 (structure data deposition date)
AuthorsToyoshima, M. / Jiang, X. / Ogawa, T. / Ohnishi, T. / Yoshihara, S. / Balan, S. / Yoshikawa, T. / Hirokawa, N.
External linksLife Sci Alliance / PubMed:31591136
MethodsX-ray diffraction
Resolution2 - 2.26 Å
Structure data

PDB-6jv9:
Crystal Structure of Human CRMP2 1-532, unmodified
Method: X-RAY DIFFRACTION / Resolution: 2.26 Å

PDB-6jvb:
Crystal Structure of Human CRMP2 1-532, AGE-modified
Method: X-RAY DIFFRACTION / Resolution: 2 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-DTT:
2,3-DIHYDROXY-1,4-DITHIOBUTANE

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-PGE:
TRIETHYLENE GLYCOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSTRUCTURAL PROTEIN / Microtubule associated protein / GAP activity / Neuronal protein

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