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| Title | An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. |
|---|---|
| Journal, issue, pages | Cell, Vol. 179, Page 417-431.e19, Year 2019 |
| Publish date | Feb 19, 2019 (structure data deposition date) |
 Authors | Maun, H.R. / Jackman, J.K. / Choy, D.F. / Loyet, K.M. / Staton, T.L. / Jia, G. / Dressen, A. / Hackney, J.A. / Bremer, M. / Walters, B.T. ...Maun, H.R. / Jackman, J.K. / Choy, D.F. / Loyet, K.M. / Staton, T.L. / Jia, G. / Dressen, A. / Hackney, J.A. / Bremer, M. / Walters, B.T. / Vij, R. / Chen, X. / Trivedi, N.N. / Morando, A. / Lipari, M.T. / Franke, Y. / Wu, X. / Zhang, J. / Liu, J. / Wu, P. / Chang, D. / Orozco, L.D. / Christensen, E. / Wong, M. / Corpuz, R. / Hang, J.Q. / Lutman, J. / Sukumaran, S. / Wu, Y. / Ubhayakar, S. / Liang, X. / Schwartz, L.B. / Babina, M. / Woodruff, P.G. / Fahy, J.V. / Ahuja, R. / Caughey, G.H. / Kusi, A. / Dennis, M.S. / Eigenbrot, C. / Kirchhofer, D. / Austin, C.D. / Wu, L.C. / Koerber, J.T. / Lee, W.P. / Yaspan, B.L. / Alatsis, K.R. / Arron, J.R. / Lazarus, R.A. / Yi, T. |
 External links | Cell / PubMed:31585081 |
| Methods | X-ray diffraction |
| Resolution | 2.15 Å |
| Structure data |  PDB-6o1f: |
| Chemicals |  ChemComp-EDO:  ChemComp-HOH: |
| Source |
|
 Keywords | IMMUNE SYSTEM/HYDROLASE / Antibody / fab / tryptase / inhibitor / IMMUNE SYSTEM / IMMUNE SYSTEM-HYDROLASE complex |
homo sapiens (human)
glycine max (soybean)