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Title | Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin ResistantStaphylococcus aureus. |
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Journal, issue, pages | Acs Infect Dis., Vol. 5, Page 1896-1906, Year 2019 |
Publish date | Jun 10, 2019 (structure data deposition date) |
Authors | Reeve, S.M. / Si, D. / Krucinska, J. / Yan, Y. / Viswanathan, K. / Wang, S. / Holt, G.T. / Frenkel, M.S. / Ojewole, A.A. / Estrada, A. ...Reeve, S.M. / Si, D. / Krucinska, J. / Yan, Y. / Viswanathan, K. / Wang, S. / Holt, G.T. / Frenkel, M.S. / Ojewole, A.A. / Estrada, A. / Agabiti, S.S. / Alverson, J.B. / Gibson, N.D. / Priestley, N.D. / Wiemer, A.J. / Donald, B.R. / Wright, D.L. |
External links | Acs Infect Dis. / PubMed:31565920 |
Methods | X-ray diffraction |
Resolution | 1.649 - 1.86 Å |
Structure data | PDB-6p9z: PDB-6pbo: |
Chemicals | ChemComp-MTX: ChemComp-NAP: ChemComp-GOL: ChemComp-HOH: ChemComp-O71: ChemComp-XNP: |
Source |
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Keywords | antimicrobial protein / oxidoreductase / DHFR / methotrexate / antifolate / NADPH |