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Structure paper

TitleStructural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945.
Journal, issue, pagesBiomed Res Int, Vol. 2019, Page 6125068-6125068, Year 2019
Publish dateJul 15, 2019 (structure data deposition date)
AuthorsLee, J.Y. / Yun, J.S. / Kim, W.K. / Chun, H.S. / Jin, H. / Cho, S. / Chang, J.H.
External linksBiomed Res Int / PubMed:31531359
MethodsX-ray diffraction
Resolution2.598 - 2.8 Å
Structure data

PDB-6khd:
Crystal structure of CLK1 in complex with CX-4945
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-6khe:
Crystal structure of CLK2 in complex with CX-4945
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-6khf:
Crystal structure of CLK3 in complex with CX-4945
Method: X-RAY DIFFRACTION / Resolution: 2.598 Å

Chemicals

ChemComp-3NG:
5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid / chemotherapy, inhibitor*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Cdc2-like kinase / Casein kinase / CX-4945 / Alternative splicing / SPLICING

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