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TitleA Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 10, Page 1346-1352, Year 2019
Publish dateAug 13, 2019 (structure data deposition date)
AuthorsPollinger, J. / Schierle, S. / Gellrich, L. / Ohrndorf, J. / Kaiser, A. / Heitel, P. / Chaikuad, A. / Knapp, S. / Merk, D.
External linksAcs Med. Chem. Lett. / PubMed:31531208
MethodsX-ray diffraction
Resolution2.52 Å
Structure data

PDB-6sjm:
Crystal structure of the Retinoic Acid Receptor alpha in complex with compound 24 (JP175)
Method: X-RAY DIFFRACTION / Resolution: 2.52 Å

Chemicals

ChemComp-LFZ:
2-[4-[3,5-bis(trifluoromethyl)phenyl]phenyl]ethanoic acid

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN / RXRA / steroid hormone receptor / inhibitor / Structural Genomics / Structural Genomics Consortium / SGC

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