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TitleA higher-order configuration of the heterodimeric DOT1L-AF10 coiled-coil domains potentiates their leukemogenenic activity.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 19917-19923, Year 2019
Publish dateMar 13, 2019 (structure data deposition date)
AuthorsSong, X. / Yang, L. / Wang, M. / Gu, Y. / Ye, B. / Fan, Z. / Xu, R.M. / Yang, N.
External linksProc. Natl. Acad. Sci. USA / PubMed:31527241
MethodsX-ray diffraction
Resolution3.6 Å
Structure data

PDB-6jn2:
Crystal structure of the coiled-coil domains of human DOT1L in complex with AF10
Method: X-RAY DIFFRACTION / Resolution: 3.6 Å

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / hDOT1L / hAF10 / Leucine zipper / heterodimer / tetramerization

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