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TitleREV7 has a dynamic adaptor region to accommodate small GTPase RAN/ShigellaIpaB ligands, and its activity is regulated by the RanGTP/GDP switch.
Journal, issue, pagesJ. Biol. Chem., Vol. 294, Page 15733-15742, Year 2019
Publish dateJul 4, 2019 (structure data deposition date)
AuthorsWang, X. / Pernicone, N. / Pertz, L. / Hua, D. / Zhang, T. / Listovsky, T. / Xie, W.
External linksJ. Biol. Chem. / PubMed:31484720
MethodsX-ray diffraction
Resolution2.002 - 2.35 Å
Structure data

PDB-6kea:
crystal structure of MBP-tagged REV7-IpaB complex
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

PDB-6nif:
crystal structure of human REV7-RAN complex
Method: X-RAY DIFFRACTION / Resolution: 2.002 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • escherichia coli (strain k12) (bacteria)
  • synthetic construct (others)
  • homo sapiens (human)
  • shigella flexneri (bacteria)
KeywordsCELL CYCLE / REV7 / MAD2B / MAD2L2 / Shigella Invasin IpaB / small GTPase

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