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Structure paper

TitleCrosslinking Allosteric Sites on the Nucleosome.
Journal, issue, pagesAngew. Chem. Int. Ed. Engl., Vol. 58, Page 15660-15664, Year 2019
Publish dateNov 6, 2018 (structure data deposition date)
AuthorsBatchelor, L.K. / De Falco, L. / von Erlach, T. / Sharma, D. / Adhireksan, Z. / Roethlisberger, U. / Davey, C.A. / Dyson, P.J.
External linksAngew. Chem. Int. Ed. Engl. / PubMed:31478581
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-6iq4:
Nucleosome core particle cross-linked with a hetero-binuclear molecule possessing RAPTA and gold(I) 4-(diphenylphosphino)benzoic acid groups.
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-AU:
Unknown entry

ChemComp-XIS:
4-diphenylphosphanylbenzoic acid

ChemComp-MG:
Unknown entry

ChemComp-D0X:
[Ru(eta(6)-p-cymene)Cl-2(pta)

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / nucleosome / anticancer / organometallic / cross-link / gold / ruthenium / DNA BINDING PROTEIN-DNA complex

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