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TitleArg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex.
Journal, issue, pagesBiochemistry, Vol. 58, Page 3990-4002, Year 2019
Publish dateApr 1, 2019 (structure data deposition date)
AuthorsDong, L. / Anderson, A.J. / Malkowski, M.G.
External linksBiochemistry / PubMed:31469551
MethodsX-ray diffraction
Resolution2.2 Å
Structure data

PDB-6ofy:
Crystal Structure of Arachidonic Acid bound to V349I murine COX-2
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-COH:
PROTOPORPHYRIN IX CONTAINING CO

ChemComp-BOG:
octyl beta-D-glucopyranoside / detergent*YM

ChemComp-AKR:
ACRYLIC ACID

ChemComp-ACD:
ARACHIDONIC ACID

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
KeywordsOXIDOREDUCTASE / Arachidonic Acid Cyclooxygenase Prostaglandin Endoperoxide Synthase / MEMBRANE PROTEIN

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