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Structure paper

TitleCrystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site.
Journal, issue, pagesSci Rep, Vol. 9, Page 12243-12243, Year 2019
Publish dateSep 3, 2018 (structure data deposition date)
AuthorsHeim, J.B. / Hodnik, V. / Heggelund, J.E. / Anderluh, G. / Krengel, U.
External linksSci Rep / PubMed:31439922
MethodsX-ray diffraction
Resolution1.54 - 1.95 Å
Structure data

PDB-6hjd:
Cholera toxin classical B-pentamer in complex with Lewis-x
Method: X-RAY DIFFRACTION / Resolution: 1.54 Å

PDB-6hmw:
Cholera toxin classical B-pentamer in complex with fucose
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-6hmy:
Cholera toxin classical B-pentamer in complex with fucosyl-GM1
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-BCN:
BICINE / pH buffer*YM

ChemComp-FUC:
alpha-L-fucopyranose

ChemComp-HOH:
WATER

ChemComp-FUL:
beta-L-fucopyranose

Source
  • vibrio cholerae (bacteria)
KeywordsTOXIN / cholera toxin / lectin / complex / Lewis-x / protein-carbohydrate interactions / X-ray crystal structure / fucose / fucosyl-GM1

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