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TitleDivergent engagements between adeno-associated viruses with their cellular receptor AAVR.
Journal, issue, pagesNat Commun, Vol. 10, Issue 1, Page 3760, Year 2019
Publish dateAug 21, 2019
AuthorsRan Zhang / Guangxue Xu / Lin Cao / Zixian Sun / Yong He / Mengtian Cui / Yuna Sun / Shentao Li / Huapeng Li / Lan Qin / Mingxu Hu / Zhengjia Yuan / Zipei Rao / Wei Ding / Zihe Rao / Zhiyong Lou /
PubMed AbstractAdeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the ...Adeno-associated virus (AAV) receptor (AAVR) is an essential receptor for the entry of multiple AAV serotypes with divergent rules; however, the mechanism remains unclear. Here, we determine the structures of the AAV1-AAVR and AAV5-AAVR complexes, revealing the molecular details by which PKD1 recognizes AAV5 and PKD2 is solely engaged with AAV1. PKD2 lies on the plateau region of the AAV1 capsid. However, the AAV5-AAVR interface is strikingly different, in which PKD1 is bound at the opposite side of the spike of the AAV5 capsid than the PKD2-interacting region of AAV1. Residues in strands F/G and the CD loop of PKD1 interact directly with AAV5, whereas residues in strands B/C/E and the BC loop of PKD2 make contact with AAV1. These findings further the understanding of the distinct mechanisms by which AAVR recognizes various AAV serotypes and provide an example of a single receptor engaging multiple viral serotypes with divergent rules.
External linksNat Commun / PubMed:31434885 / PubMed Central
MethodsEM (single particle)
Resolution3.07 - 3.3 Å
Structure data

9794

6jcq

EMDB-9794, PDB-6jcq:
AAV1 in complex with AAVR
Method: EM (single particle) / Resolution: 3.3 Å

9795

6jcr

EMDB-9795, PDB-6jcr:
AAV1 in neutral condition at 3.07 Ang
Method: EM (single particle) / Resolution: 3.07 Å

9796

6jcs

EMDB-9796, PDB-6jcs:
AAV5 in complex with AAVR
Method: EM (single particle) / Resolution: 3.18 Å

9797

6jct

EMDB-9797, PDB-6jct:
AAV5 in neutral condition at 3.18 Ang
Method: EM (single particle) / Resolution: 3.18 Å

Source
  • adeno-associated virus - 1
  • homo sapiens (human)
  • adeno-associated virus - 5
KeywordsVIRUS / adeno-associated virus / AAV1 / receptor / AAVR / AAV5

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