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TitleSustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Journal, issue, pagesNat Commun, Vol. 10, Page 3758-3758, Year 2019
Publish dateNov 14, 2018 (structure data deposition date)
AuthorsSpangenberg, E. / Severson, P.L. / Hohsfield, L.A. / Crapser, J. / Zhang, J. / Burton, E.A. / Zhang, Y. / Spevak, W. / Lin, J. / Phan, N.Y. ...Spangenberg, E. / Severson, P.L. / Hohsfield, L.A. / Crapser, J. / Zhang, J. / Burton, E.A. / Zhang, Y. / Spevak, W. / Lin, J. / Phan, N.Y. / Habets, G. / Rymar, A. / Tsang, G. / Walters, J. / Nespi, M. / Singh, P. / Broome, S. / Ibrahim, P. / Zhang, C. / Bollag, G. / West, B.L. / Green, K.N.
External linksNat Commun / PubMed:31434879
MethodsX-ray diffraction
Resolution2.25 Å
Structure data

PDB-6n33:
Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

Chemicals

ChemComp-622:
6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / CSF-1-R / FMS PROTO-ONCOGENE / C-FMS / CD115 ANTIGEN / KINASE / ATP-BINDING / PLX5622 / TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX

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